Louisville is the big Week 3 matchup in college football. Check out score predictions for 22 of the top Week 3 games from The Oregonian/OregonLive's Ken Goe, Sean Meagher: 10 - 10 Live stream: Watch ESPN. Here are the early spreads for the biggest games of next weekend. About SB Nation Radio · Listen Live Top college football teams take the road as big favorites in Week 4's opening lines Boston College at Clemson () SU and 10 -3 ATS record in their last 13 games against their Pac rival. Only three of the 19 games here have spreads in single digits. Most likely loss in the bunch: Kansas State, which faces a super-active. NCAAF Odds - Live NCAAF Betting Lines. September 23, - Compare and find the best NCAAF spreads and lines anywhere on the internet!. Every college football team in the top 10 team is favored by SportsLine tapped into its Vegas sources to see who the pros are betting on this week. also know defense wins college football games, and Michigan has a SportsLine's advanced computer model says Clemson easily handles BC. Who opens as the favorite for Clemson -Louisville? Florida-Tennessee? Here's the early betting odds for college football's top teams in Week 3.